![]() ![]() ![]() ![]() For the main segments of the circle of Willis, Kappa values between TCD and MRA for the anterior cerebral arteries, middle cerebral arteries and posterior cerebral arteries were 0.91, 0.72, and 0.47, respectively. As a result, the proportion of familial MMD patients increased from 7% (38/527) to 15% (79/527) in this period. Another 41 cases of familial MMD cases were identified, which included 21 family members and 20 corresponding sporadic MMD patients who had family members confirmed positive with MMD. In this study, 285 immediate family members of 245 sporadic MMD patients were screened. The immediate family members of MMD patients were initially screened by transcranial Doppler sonography (TCD) and positive cases were verified by magnetic resonance angiography (MRA).įrom July 2011 to March 2013, there were 527 MMD patients managed in our hospital, including 38 familial MMD cases. In this study, we focused on family members of sporadic MMD patients, and aimed to gain a clearer understanding of the role that genetic factors play in MMD. Previous studies concentrated on familial MMD patients. Genetic factors play an important role in the pathogenesis of moyamoya disease (MMD). ![]()
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